Chromatography since its inception has experienced a full century of development has today become the most important separation and analysis of science, widely used in many fields, such as petrochemicals, organic synthesis, physiology and biochemistry, medicine and health, environmental protection, and even space exploration . In recent decades, chromatography has been greatly developed as a powerful separation technique with MS and other detection methods. GC-MS and HPLC-MS are widely used in stimulant testing and food safety analysis. Ion chromatography technology is conducive to the upgrading of water quality testing With the development of modern industry, the issue of environmental protection has drawn great attention of the whole society. As an important resource of natural environment, water is becoming more and more serious. With the widespread use of ion chromatography, the detection technique of ion chromatography has evolved from a single chemosuppressive conductivity method to a method that includes electrochemical photochemistry and is used in conjunction with many other analytical instruments. 1, inhibition of conductivity detection method; 2, direct conductivity detection method; 3, UV absorption spectrometry; 4, post-column derivatization spectrophotometry; 5, electrochemical method; 6, and elemental selective detector combination. Water quality monitoring is to monitor and determine the types of pollutants in water, the concentration of various pollutants and trends, the process of assessing water quality. The main water quality monitoring programs can be divided into two broad categories: one is a comprehensive indicator of water quality, such as temperature, color, turbidity, pH, conductivity, suspended solids, dissolved oxygen, COD and biological requirements Oxygen and so on; the other is some toxic substances, such as phenol, cyanide, arsenic, lead, chromium, cadmium, mercury and organic pesticides. In order to objectively assess the status of water quality in rivers and oceans, in addition to the above monitoring items, it is sometimes necessary to measure the flow rate and the flow rate. Ion chromatography detection, simultaneous analysis of a variety of ionic compounds. Gas chromatography is widely used in food safety testing In order to ensure food safety, food safety testing methods need to be adopted in the fields of food and agriculture, covering the whole process from the control of raw materials and processing processes to the inspection of finished products and the sale of products. At the present stage, gas chromatography technology mainly includes these categories for food safety testing: first, analyzing the residues of pesticides in vegetables, fruits and tobacco; second, analyzing veterinary drug residues and trimethylamine contents in livestock and poultry, aquatic products; thirdly, Analysis of contaminants in drinking water; Fourth, analysis of food additives and the type of content. Thus, gas chromatography in the field of food quality and safety testing has been widely used and promoted. Among the features of GC technology are high sensitivity, such as those easily detectable at concentrations less than or equal to 1 ppm (10-6), and pesticide residues ranged from ppb (10-9) to ppt (10-12). Its higher separation efficiency is mainly reflected in a packed column with a length of 1 to 2 meters. There are several thousands of theoretical plates and 105 to 106 theoretical plates for capillary columns. The analysis speed is mainly reflected in the complex sample analysis, the analysis time is usually controlled within a few minutes to tens of minutes, while automation easier to achieve. Liquid chromatography single quadrupole mass spectrometer assisted boost detection Chromatography was used in doping controls in 1967, capillary gas chromatography in 1980, basic setting in 1984, and the addition of high performance liquid chromatography for the determination of several specific drugs and caffeine. In 2008 Beijing Olympic Games doping test using a liquid chromatography single quadrupole mass spectrometer for thousands of urine samples for diuretics, masking agents and other banned substances detection. The test results were accurate and reliable, athletes using diuretics were detected, and two control samples added by WADA to the doping control sample were detected without any missed inspection. The detection sensitivity was relatively high, meeting WADA Minimum detectable capacity (MRPL) requirements. Instrument working conditions are stable, easy to operate, high degree of automation in the data analysis software used to write the MACRO instructions, test data easy to identify and determine the use of this instrument to detect diuretics and other masking agent detection tools, is the regular and large-scale games excited A good method of agent testing. 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