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Nucleotides, as deep processing products of nucleic acid (RNA), are widely used in medicine, food, agriculture and other fields. Previously, nucleotide production technology was monopolized by a few countries such as the United States, Japan, South Korea, and Germany, and it imposed a 30-year technical blockade on China. During the "6th Five-Year Plan" period, the state organized scientific research institutions to tackle the problem, and domestic single nucleotides have not yet achieved industrial production. The annual output has hovered around 25 tons, of which Shandong Shuangfeng has an annual output of 20 tons. Mononucleotide nucleotides are high-value-added products. At present, the international price is nearly 280,000 US dollars per ton, and China will import about 180 tons per year. Due to the foreign technology blockade, China's imported monomeric nucleotides are all food-grade, not pharmaceutical-grade, with content below 90%, which has long restricted the nucleotide industry and its downstream medicine, food, health products, agriculture, etc. Industry development.
Shandong Shuangfeng Co., Ltd. is the earliest company to develop single nucleotides in China. In June this year, the company started construction of a 100-ton/year high-purity single-nucleotide nucleotide project. This project was designated as a National High-tech Industrialization Demonstration Project by the National Development and Reform Commission and allocated 6 million yuan. Local governments also provided financial support. .
This project adopts a patented technology jointly developed by Shuangfeng Company and East China University of Science and Technology, which has many advantages: the highest conversion rate of nucleotides can reach 95%, which is 15% higher than that of traditional processes; the total yield is increased from the original 35%. To 67%, the product content can be increased from the original 90% to 98%; the production cost is greatly reduced, the production cost of the enzyme accounts for the proportion of the total cost is reduced from 15% to 1.5%; realize the zero of waste gas, waste water, waste residue Emissions; a change in the traditional technology process can only spring, autumn and winter three quarters of the production model, to achieve continuous uninterrupted large-scale industrial production throughout the year. After the project is put into production, annual sales revenue will increase by 180 million yuan and profit and tax will be 28 million yuan.
Recently, it was learned from Shandong Shuangfeng Industrial Park that Shandong Shuangfeng Co., Ltd. invested 65 million yuan, adopting proprietary enzymatic technology and separation and purification technology to build 100-ton/year high-purity monomer nucleotides (Phase 1) The project is progressing smoothly and it is expected to be completed and put into operation before the end of the year. By then, China's nucleotide industry will completely break the monopoly of foreign technology, achieve industrial production, rewrite the history of the product's long-term reliance on imports, and have an important impact on downstream related industries.